Prolactin, testimony for assignment, the rules for preparing for the analysis, decoding the results and indicators of the norm.

IMPORTANT!

Information from this section cannot be used for self-diagnosis and self-treatment. In case of pain or other exacerbation of the disease, diagnostic studies should appoint only the attending physician. To make a diagnosis and proper appointment of treatment, you should contact your attending physician.

We remind you that the independent interpretation of the results is invalid, the information below is solely reference.

Prolactin: testimony for the purpose, the rules for preparing for the analysis of analysis, decoding the results and indicators of the norm.

Indications for the purpose of the study

The blood test for prolactin can be assigned in the presence of selections from the mammary glands outside the child feeding. Such a violation occurs, including non-women, men and even children, it is not an independent disease, usually accompanies hormonal disorders or the result of some drugs. Ultrasound diagnosis of organs located in a small pelvis;Different disorders of the menstrual cycle are irregular menstruation, lack of menstruation 6 or more months, strengthening menstrual bleeding (by the number of days and / or volume of lost blood), the lack of ripening eggs - are also an indication of the surgery.

The study is carried out in the framework of the establishment of the cause of infertility, with a violation of lactation in the postpartum period, with severe climax, a decrease in libido and potency in men.

Regular examination is recommended for controlling therapy prolactin.

Preparation for the procedure

Two days before the study, it is necessary to try to eliminate stressful situations and physical exertion, including sex classes, as well as thermal procedures (visits to baths, saunas) and taking alcohol. Analysis for prolactin is given in the morning, 2-3 hours after awakening , Strictly on an empty stomach after the night of starvation from 8 to 14 hours.

According to the preparation rules, it is not recommended to smoke at least within one hour before the study. Before passing an analysis, it is necessary to be at rest for 20-30 minutes.

Women with a preserved menstrual cycle should be discussed with the attending physician preferred days for surrendering analysis. It is usually recommended to perform a study in the first phase of the menstrual cycle (on the 3-5th day after the start of menstruation), but sometimes, depending on the testimony, the analysis can be assigned out of return on the cycle day or in its second phase (21-23- y day).

Period of execution

1 working day (not including biomaterial day).

What can affect the results

In case of non-compliance with the preparation rules, the results obtained may be incorrect. In addition, acute inflammatory processes in the body can be influenced by the accuracy of the study (for example, ORVI, pneumonia, pyelonephritis, etc.) and injuries of the chest, so the analysis on prolactin is recommended not to take no earlier than two weeks after recovery.

Prolactin values ​​may vary from and at the reception of certain drugs: for example, some psychotropic drugs (neuroleptics, antidepressants), hormonal, anticonvulsant, antitumor, individual hypotensive drugs, some gastroenterological means and some others. It is necessary to inform the attending physician about their reception and discuss the feasibility and the ability to cancel before passing the analysis.

Prolactin (ProLactin) (+ additional test on macroprolactin with a prolactin is higher than 700 honey / l)

Blood on the analysis is taken from Vienna.

Rent analysis to prolactin

You can in the nearest medical office of Invitro. The list of offices where the biomaterial is accepted for laboratory research is presented in the "Addresses" section.

The interpretation of the results of the study contains information for the attending physician and is not a diagnosis. Information from this section cannot be used for self-diagnosis and self-treatment. The proximity is set by the doctor using both the results of this survey and the necessary information from other sources: anamnesis, the results of other surveys, etc.

Definition limits: 12.6 - 172200 honey / l.

Units of measurement in an independent Invitro laboratory: honey / l.

Alternative units: ng / ml.

Recalculation of units: ng / ml x 21 => honey / l. Reference values
Age Prolactin level, honey / ml
Men Women 0-1 months.
78-1705 (in the neonatal period, the original level with a rapid decline in the next 4-8 weeks) 6.3-1995 (newborn has a high level with a rapid decline in the next 4-8 weeks) 1-12 months.
<607. <628. Over 1 year old

73-407.

109-557

Decoding indicators

The level of prolactin in the blood depends on age, gender, pregnancy or lactation, which should be considered when deciphering the results. In the first year of life, the concentration of prolactin is high. Subsequently, it gradually decreases. During pregnancy, the amount of hormone grows, starting from the 8th week, and reaches a peak by the 22-25th week, and after the 36th week gradually decreases. Physiological (normal) increase in prolactin is recorded during lactation.

What are the reduced indicators mean

Prolactin, like some other hormones (ACTH, FSH, LG, TG), is synthesized in the pituitary gland, which controls the operation of adrenal glands, ovaries, thyroid gland, mammary glands, and also regulates the growth and development of the body. Various damage to the pituitary gland can be accompanied by a decrease in the level of prolactin and other hormones.

The reduced prolactin indicators are noted under the shyhan syndrome (severe neuroendocrine pathologies arising from women after abortion and complicated childbirth). In parallel, the decrease in the function of the thyroid gland, adrenal glands, ovaries is developing.

Violation of the pituitary function (and, accordingly, a decrease in the level of prolactin) can be observed as a result of injury, after surgery and radiation therapy.

Some reduction in the concentration of the hormone is detected by increasing blood sugar - with diabetes, violation of glucose tolerance.

The decrease in prolactin is possible when receiving some drugs: antiepileptic, dopamyerghetics, estrogen, dexamethasone, cyclosporine A, morphine, nifedipine, rifampicin.

What are the increased indicators

The reason for increasing prolactin is often the various diseases of the hypothalamus and pituitary gland. The hypothalamus is the brain department, a link between the central nervous and an endocrine system, which through the pituitary is controlling the entire endocrine system of the body.

  • The increase in prolactin can be associated with different endocrine diseases: a decrease in the function of the thyroid gland, polycystic ovary syndrome, the insufficiency of the adrenal cortex.
  • Other probable reasons:
  • severe internal organs (chronic renal failure, liver cirrhosis);
  • Tumors producing estrogens;
  • damage to the chest;
  • Reducing sugar level caused by insulin;

shingles;

Reception of some drugs (neuroleptics, estrogens and some others).

Additional examination with the rejection of the indicator from the norm

Patients with prolactin level, inappropriate norm, observe an endocrinologist and a gynecologist. Not all cases of increasing prolactin, especially if it is a slight increase, require therapy; Sometimes enough dynamic observation.

The test for the presence of macroprolactin is carried out as an additional study in the detection of an increased level of thoroughtine (above 700 honey / l). Implementation of the study on macroprolactin does not increase the cost of determining the main indicator.

Macroprolactin is an inactive form of a hormone, so the increase in prolactin at the expense of Macroprolactin does not give clinical manifestations and does not require the appointment of additional surveys and drug therapy.

When changing the level of prolactin, the study of other pituitary hormones has been appointed (ACTH, LH, FSH, TSH)

, as well as sex hormones (testosterone and progesterone).

Hormones belong to one of the most unexplored substances in the body. Thanks to them, the organs correctly perform their functions, but the failure almost always becomes the cause for the development of diseases. One of the most controversial is prolactin, which is produced in the pituitary. On the one hand, thanks to him, women appear breast milk after the birth of the baby, on the other - its number increases during stress. The latter can be a prerequisite for hormonal imbalance.

Prolactin is considered to be a female hormone, since it is produced during breastfeeding and maintains the existence of a yellow body in the ovary.

This is a hormone produced in the front of the pituitary. Its formation is due to the dopamine, which is produced by the nuclei of the hypothalamus. Finding with the help of a blood circulation system in the pituitary gland, it leads to blocking prolactin. It reduces it and progesterone appearing in women after ovulation.

  • The substance is a single-chain polypeptide. It has 199 amino acids. In one molecule, there are three disulfide bridges. Due to heterogeneity, the analysis molecule may show different results. Prolactin receptors are in lactic glasses of liver, kidneys, pancreas, adrenal glands, muscle frame, leather and in some sections of the central nervous system.
  • The largest amount of hormone is produced in the phase of deep sleep and immediately after awakening. Over time, its number decreases. The stress hormone performs several functions:
  • participates in the formation of secondary sexual signs in women during the period of development;
  • suppresses the possibility of ovulation during breastfeeding;
  • has an anesthetic effect;
  • reduces the level of other hormones;
activates the correct immune response;

Stimulates the balance of various substances in the body.

Medicas note that all the features of the hormone described are still not identified. Modern studies are aimed at obtaining a complete picture of it, its functions.

Against the background of physical overwork, with a violation of psychological or mental equilibrium, the amount of prolactin in the blood increases sharply. If there is a traumatic factor, physiological changes occur. The most susceptible to different aggressors of endocrine fabrics.

At the first signs of danger, adrenal glands begin to work. They are produced by adrenaline and norepinephrine. The values ​​of the first increase when alert, various shock conditions, fear. When entering the blood, it leads to an increase in the heartbeat and the expansion of pupils. Too long exposure to adrenaline becomes the reason for reducing the protective forces of the body.

Noraderenalin is allocated under strong stress, mainly leads to an increase in blood pressure. If adrenaline is differently called "hormone of fear", then "Noraderenalin" - rage.

With severe physical exertion, cortisol is produced. It does not have too much influence on the body, but when it accumulates, constant exposure, there is a sense of depression, it appears for products with a large content of glucose.
In a chain of biochemical reactions, prolactin is also involved in stress. It appears not only in a state of stress, but also depressed. Against the background of its excessive increase, there is a violation in the metabolism. It is necessary to protect the body: special mechanisms are launched, allowing a person to adapt to new conditions.

In small doses, stressful hormones regulate the state of a person, but at high volumes begin to cause harm. A particularly strong negative effect of substances have in chronic stress.

  • The increase in prolactin becomes the cause of chronic fatigue and sleep disorders.
  • Prolactin regulates the operation of the sexual system, affects the metabolism. When stressing, it occurs an instant increase in the blood. This launches a number of pathological processes:
  • anorexia;
  • polycystic ovarian syndrome;
  • cirrhosis of the liver;
  • raising cholesterol and blood pressure;

violation in sleepy cycles;

thinning of the skin.

Different consequences are observed in men and women. Representatives of the strong gender, with an increased number of stress hormone, there is a weakening of potency, the absence of sexual entry. This is related to a decrease in the generated genital hormones and spermatozoa. There is a sharp decrease in testosterone (male hormone), intensive estrogen production (female hormone).

If the level of prolactin rose against the background of physical overwork, excessive loads, the time reaction does not affect hormonal equilibrium. In other cases, protracted depressions are possible, the appearance of excess weight, a decrease in life tone, infertility and impotence.

  • Since testosterone and prolactin depend on each other, the larger the prolactin in the body, the less testosterone. Accordingly, the lower the level of the male hormone, the more different problems may occur.
  • With a long-term increase in prolactin not related to breastfeeding, a violation of the menstrual cycle may be observed. Sometimes this symptom is the only complaint. Additionally, it may appear:
  • Infertility. It is due to the fact that the woman does not occur ovulation, and therefore the conception of the child.
  • Hyperastroy. An increased amount of estrogen occurs. Because of this, the amount of natural lubrication released is reduced, the libido is reduced. Against the background of long flowing reactions, the uterine, endometriosis, osteoporosis can develop.
Obesity. The increase in hormones leads to increased meal consumption, especially sweet. Because of this, a larger amount of subcutaneous fatty fiber is formed.

Worsening vision. With long-term hyperprolactinemia, an increase in pituitary cells occurs, which is localized next to visual nerves. This leads to a deterioration of vision.

With prolonged stress and depressions, the uncontrolled hormone production begins, which may result in the formation of cancerous tumors.

Recommend to pass tests to the level of prolactin can any doctor. But when the elevated values ​​are identified, consultation is assigned from the endocrinologist. Blood for research can be taken several times, since the increase in prolactin depends on the level of asocial mood and overall well-being. For this reason, it is recommended to diagnose with an interval of 10 days. Optimal time - 2-3 hours after awakening. If hyperprolactinemia is stored in several samples, doctors can assume the presence of serious pathologies.

  • Diagnostics include laboratory and hardware research methods, allowing to find the cause of the increase in stress hormone.
  • In addition to the analysis of blood, additional research can be appointed. It:
  • Ultrasound

X-ray examination,

MRI.

Ultrasound is more often appointed to women to examine the mammary glands. The method confirms the presence of increased volume of iron tissue. In men, ultrasound allows you to reveal a decrease in the sizes of the testicles.

MRT allows you to show adenoma, some types of tumors. The neoplasms are examined by contrasting substances that are injected intravenously. Additionally, a radiograph is used to reveal the pituitary tumors.

  • Thus, hardware studies allow you to determine the root cause at which an increase in stress hormone in the body has occurred. When studying for other hormones of stress, you can assume the presence in the life of traumatic factors that determine the cause of the failure of the work of systems and organs.
  • No need to treat with elevated indicators if:
  • Hormone concentration up to 1000 U / l;
  • The structure of the pituitary is not changed;

The work of the organs of the sexual system occurs unchanged;

  • Man has a normal weight.
  • The main assistant in the fight against increased prolactin is dopamine. They "compete" among themselves, creating a balance. To normalize the state, it is recommended to deal with what brings pleasure, give the body time for rest. The positive effect on the hormonal background is provided:
  • bananas
  • apples
  • watermelons
Strawberry,

prune.

A good relaxing effect is a massage that allows you to normalize emotional state.

Reduce the level of stress hormone can be regular physical exertion. They should not be exhausted, as it can become a prerequisite for its increase. The optimal option is to carry out gymnastics in a well-ventilated room or on the street.

Before bed, you can do and make soothing infusions, which contains mint, Melissa and Hmel. Lower the level of anxiety and tablets with valerian extract. When using the Pruck, give preference to the tincture of seeds. For this, 40 gr. Raw materials are poured with alcohol or vodka in the amount of 230 gr., insist for two weeks in a dark place. A tincture of a large spoon, divorced in 60 ml, is accepted. Water 30 minutes before meals.

With drug treatment, different therapeutic techniques for women and men are used. They are also addressed only if in other ways to reduce the level of hormone does not work.

The main rule - listen to your body. In hormonal changes against the background of stress, unfortunate heartbeat and anxiety appears. Sleep ceases to give a feeling of rest. In the morning there is fatigue, fog in the head, pain in the muscles. There is a decrease in sexual attraction and failure in food behavior.

It is necessary to give time for rest and relaxation. Try to spend more time in the fresh air. Do not forget about communication that helps reduce the level of anxiety, switch to positive experiences.

Thus, prolactin is a greater degree of a female stress hormone, since its increase is more often observed in representatives of weak gender. The increase in certain substances in the body is a protective effect. But in the absence of a state adjustment, physiological problems appear. Therefore, it is important to monitor your emotional state.

Last updated: 12/13/2019

Doctor obstetrician gynecologist of the highest category

Evaluation of the general hormonal profile.
Head of the gynecological separation of a network of multidisciplinary clinics "Medgard-Saratov"

Prolactinum - a hormone, which is of great importance to the human body - both for a woman and for a man. The main biological role is the growth of the mammary glands and the regulation of lactation (Lactatio), in addition, it has hypotensive, metabolic and other effects. In the female body, the increase in the level of prolactin (also known as Mammotropin also known) can be an obstacle to conception and normal course of pregnancy. Therefore, it is imperative to track the level of this hormone in the blood in order to detect pathology on time.

Below, we will consider the symptoms of such a violation, we will tell what is the danger, what are the consequences of an increased monomer prolactin in women, to which it affects why deviations are due to the norm in the secretion of this hormone, and is it possible to get pregnant with increased prolactin.

Milk iron.jpg.
Prolactin and his role for a female body

What is prolactin and what is his role in the body of a woman?

  • The secretion of this hormone is carried out by lactotropic cells of the pituitary gland, as well as extraordinate sources, for example, the placenta, lactic glands, cisheloid iron, immune system, some tumors, etc. Important influence on its production and estrogens are rendered: when the concentration of dopamins decreases, an increase in the number of prolactin is observed; The same happens when the content in the blood of estrogen is raised.
  • Norma prolactin in women
  • This hormone performs important tasks that ensure the normal functioning of the female organism:
  • During the lactation, it is responsible for the ripening of the colostrum, turning it into breast milk and the exercise of breastfeeding.
  • During puberty affects the growth of teenage girls breast. The same occurs during pregnancy, as the hormone stimulates the development of the mammary glands and their preparation for the subsequent lactation process.
  • During pregnancy, prolactin provides metabolic processes in an oily fluid, due to which its quantity and composition is regulated.
  • In the postpartum period prevents the onset of ovulation and blocks the possibility of the new pregnancy until the woman feeds the child with breasts.

It takes part in the regulation of the menstrual cycle, since its number affects the secretory activity of the yellow body in the ovaries, progesterone production and subsequent ovulation.

 

It affects the normal functioning of the kidneys, the fat exchange and operation of the immune system.

Participates in the formation of the feeling of excitation and orgasm during intimate proximity.

If you have found a mistake, please select the text fragment and click
So, the effect of prolactin on the normal functioning of the body of a woman is huge. Not only feminine health depends on the amount of its production and blood content in the blood, but its ability to the birth of children.

From what is raised prolactin in a woman: the causes of physiological nature

The view is that the increased level of prolactin in women (this phenomenon is called hyperprolactinemia) is an exclusively sign of pathology, erroneously. In fact, the development of this hormone is intensified not only in case of certain violations, but also under the influence of absolutely normal physiological factors.

Prolactin is raised by a woman, reasons

Usually prolactin is elevated by a woman during pregnancy. The growth of the content of this hormone in the blood during the nesting period of the baby is due to the active development of other hormones - estrogen. Estrogens are directly involved in the process of formation of prolactin: the growth in the blood content of estrogen leads to an increase in cells responsible for separating prolactin. It is necessary to prepare the body of the future mother to the lactation process after childbirth. Although during pregnancy prolactin is elevated almost the same as during breastfeeding, the lactation process cannot be started due to the large content of progesterons (PROGESTERONUM) - this happens until the placenta is released.

After childbirth and the release of the placenta, the content of estrogen in the blood decreases sharply, and the number of prolactin increases.

Hormone prolactin, video

The prolactin hormone is raised in women not only during pregnancy, but also in the postpartum period - when feeding the child with breasts. The process of sucking the chest involves the stimulation of the nipples and the mechanoreceptors located on them, as a result of which the corresponding signals are received in the hypothalamus on the need to isolate breast milk.

The increased content of this hormone in the blood may not be completely connected with maternity. It is observed before the monthly, during stressful situations, physical exertion, sports, with severe pain, hunger, sex, stimulation and stimulation of nipples, even just during sleep. Also, short-term increase in the level of the hormone can be observed after gynecological studies, carrying out ultrasound of the breast, blood intake for analyzes and other medical manipulations. In addition, the level of prolactin fluctuates during the day: after waking, it is much higher than after 2-3 hours of wakefulness.

All of these factors indicate that the signs of increased prolactin far do not always testify to the presence of pathology.

  • What is still raised prolactin: the causes of pathological disorders
  • Prolactin is produced by both women and men, however, pathological violations of the secretion of this hormone are mainly found in the female half of the population. This is due to the features of the endocrine system of women.
  • Among the prerequisites that affect the pathological increase in the production of this hormone, the following can be distinguished:
  • The presence of malignant and benign formations affecting the pituitary gland or hypothalamus.
  • Infiltrative diseases of the hypothalamus.
  • Arteriovenous vices.
  • Syndrome cut the legs of the pituitary.
  • Adenoma and prolactinity pituitary.
  • The "empty" Turkish saddle syndrome.
  • Systemic red lupus (Lupus Erythematosus).
  • Primary hypothyroidism (hypothyreosis).
  • Abuse of alcoholic beverages and narcotic substances.
  • Therapy with the use of some drugs (antidepressants, psychotropic drugs, tranquilizers, antiemetic medicines, etc.)
  • Reception of oral contraceptives.
  • Hormonal therapy (in particular - taking estrogen).
  • Disorders of the functioning of the thyroid gland.
  • Polycystic ovarian syndrome.

The impact of radioactive radiation.

Chronic renal and liver failure, liver cirrhosis.

  • Chest damage.
  • How to find out that prolactin is elevated: symptoms of hyperprolactinemia
  • The symptoms of increased prolactin in women are manifested as follows:
  • There are significant disorders of the menstrual cycle, accompanied by long delays. This symptom of the elevated level of prolactin is found in women more often than other manifestations of this pathology. Menstruation is scarce, irregular or may be absent at all.
  • The absence of ovulation and, as a result, infertility. Due to the fact that the yellow body does not ripen and no ovulation occurs, as well as due to the reduction of the luteane phase of the menstrual cycle, the fertilization of the matched egg is impossible. This leads to infertility.
  • Loss of pregnancy for a period of up to 12 weeks caused by neuroleptic hyperprolactineia.
  • Increase and heat of the mammary glands. This usually occurs in the second half of the menstrual cycle. However, in some cases, an increase in breast volume, a feeling of cutting and soreness accompany the woman throughout the entire cycle.
  • Selection of milk nipples, not related to breastfeeding. This phenomenon is called a galattere. The amount of milk can fluctuate from 1-2 drops, which appear when squeezing the nipples or their sucking, to spontaneous milk leakage.

Excessive body exhaust, the appearance of acne and acne from increased prolactin is observed in about 20% of cases.

Prolactin, norm
Reducing sexual attraction, no excitation and orgasms.

Violation of metabolism, manifested in high appetite and excess weight set.

  • What consequences have signs of increased prolactin in women?
  • What consequences can be an elevated level of prolactin in the body of a woman?
  • If the level of hormone generation significantly exceeds normal indicators, it can be dangerous for women's health. In addition to disorders of the menstrual cycle, the lack of ovulation, problems with conception and having tooling the child, the following unpleasant and even dangerous conditions may be observed:
  • Frigidity (Frigiditas), a decrease in sexual attraction, lack of orgasms, which may be observed in the appearance of tensions between partners.
  • Syndrome of giant mammary glands. If the chest lights slightly, causing a small discomfort, it is not very dangerous. But if there is a significant increase in the mammary glands, it may be a disturbing woman's health sign: due to increased prolactin, chest hurts, cyst and oncology formation may be observed.
  • Disorders of psycho-emotional background up to social disadptation, autoculation, depression, psychosis and other mental abnormalities.
  • The risk of developing increased pressure and ischemic heart disease, observed due to metabolic disorders appears.
  • Obesity caused by an increase in appetite, a set of excess weight and failures in metabolic processes.
  • Diabetes of type II diabetes.
  • Development of osteoporosis (osteoporosis) as a result of a reduction in bone mineral density. Osteoporosis leads to brittleness of bone tissue and its fractures.

There is a risk of autoimmune diseases.

 

Sleeping disorders, memory, attentiveness, increased fatigue, apathy, weakness are observed.

There are disorders of the vegetative nervous system.

If hyperprolactinemia is caused by the pituitary adenomas, there is a chance of development and other consequences dangerous. Among them is to highlight hypocituitarism (Hipopituitarismus), paralysis of extracilla muscles, limiting field fields, reduction of visual acuity. Opinion expert

Numerous studies that were conducted to study the impact of an increased level of prolactin on the human body have shown that hyperprolactinemia provokes a change in food behavior, thereby promoting obesity.

Doctor obstetrician gynecologist of the highest category

Oksana Anatolyevna Garthleb

Is it possible to get pregnant with increased prolactin?

One of the main difficulties faced by many couples while trying to conceive a child - elevated prolactin in a woman. Pregnancy in this case does not occur until the hormone level comes to normal. However, this is not the final sentence. After carefully conducted examinations, the reasons for the increased secretion of the hormone and the appointment of the course of suitable medicines pregnancy still comes. Usually for treatment and preparation for conception goes about a year.

Prolactin raised
Elevated prolactin and pregnancy

Improving the level of hormone during a baby tooling is a normal physiological phenomenon. However, if a woman had prolactin, before pregnancy, it was necessary to undergo a regular inspection at the endocrinologist and an ophthalmologist.

Diagnosis and treatment of elevated levels of prolactin: what to do in the first place?

  • Hormone prolactin raised
  • If you have found signs of hyperprolactinemia, first of all, it is necessary to find out why prolactin is increased: the definition of the root cause is largely affected by the choice of appropriate drugs for the treatment of this disease.
  • For the formulation of an accurate diagnosis, diagnosis is necessary. It usually includes a fence of venous blood for laboratory studies, which is carried out three times to obtain the most accurate results. Before surrendering blood for analyzes, it is necessary to follow some of the rules of preparation:
  • A day before the blood fence, exclude sex and any other sex contacts.
  • Limit physical and psycho-emotional loads, stressful situations.

Refuse to visit the sauna on the eve of the analysis.

The day before the blood fence, exclude alcohol and smoking.

Blood surrender strictly on an empty stomach.

  • Blood surrendered in the morning, but not later than 3 hours after awakening. It is advisable to do it in the period from 9 to 11 am, as closer to noon the content of the hormone in the blood rises.
  • Normally, the indicator of the level of prolactin in the blood in women of reproductive age, not pregnant and non-nursing breasts, is 40-530 mmes / l (1 ng / ml = 30.3 mme / l). At the same time, some medical sources call other permissible figures, which is associated with the phases of the menstrual cycle, a period of pregnancy. If prolactin is greatly enhanced, it may indicate the presence of macroenomes. In this case, the doctor will send a patient to MRI using contrasting substances or on computed tomography. These diagnostic methods allow us to obtain information on the presence / absence of a pituitary tumor and its size.
  • To confirm the diagnosis and appointment of the necessary therapy, the doctor may advise additional surveys. These include:
  • Laboratory studies of venous blood for determining the amount of hormones contained in it -LG, FSH, TSH, Macroprolactin, progesterone, testosterone, estrogen, etc. There are cases when there are simultaneously levels of multiple hormones.
  • General and biochemical blood tests and urine to clarify the level of sugar, bilirubin, cholesterol, urea, lipid profiles.
  • Examination at the endocrinologist with the ultrasound of the thyroid gland. Disorders of the thyroid gland functions often cause hyperprolactinemia in women, so the doctor is important to confirm or refute suspicion of hypothyroidism.
  • A visit to the gynecologist with an ultrasound of a small pelvis organs. Since one of the common causes of hyperprolactinemia is polycystic ovary syndrome, the ultrasound is not just desirable, but necessary.
  • Ultrasound or radius of the mammary glands (depending on the age of the patient). This survey is necessary to establish the number of Milky Ducts and determining the quality of the supply of their blood.
  • Ultrasound of the abdominal organs. The study is aimed at analyzing the size and functioning of the kidney and the patient's liver.
  • X-ray skull to determine intracranial pressure. If a prolactine or other tumor has a place, intracranial pressure increases. This can be a prerequisite for the subsequent direction to conduct an MRI brain.
  • Ophthalmological examination. Since adenoma can put pressure on extracular muscles, the doctor checks the fields of view, conducts a study of the eye bottom and measures the eye pressure.

Pharmacological samples.

Bone tissue studies. They are necessary to establish the degree of probability of development of osteoporosis.

Observation of the body of the patient after canceling medications capable of increasing the level of prolactin in the blood. This method is used in cases where the woman undergoes treatment with the use of tranquilizers, antidepressants, etc. (see list above). Reception of drugs is canceled by 3 days if it does not bring the patient harm. At this time, the woman should be in the hospital for constant control of prolactin.

After establishing the root causes of the disease, suitable therapy is assigned. How to treat not only symptoms of increased prolactin, but also to affect the cause of violation of the mining of hormone, the doctor should solve. In some situations, hyperprolactinemia does not require special treatment, and passes independently. If the patient has a slightly increased concentration of hormone in the blood (up to 1000 honey / l), there are no changes in the functioning of the pituitary. Ovulation is present and the normal body mass remains, treatment is not appointed.

But in more complex cases without an individually selected course therapy can not do. The main task in the treatment of hyperprolactinemia is to achieve the normal content of the hormone in the blood and the restoration of ovulation, especially if the woman is preparing for conception.

If there is a prolactine or other tumor, it is important to choose therapy that allows you to reduce the volume of the neoplasm.

Treatment of increased prolactin implies medication therapy. If it does not bring positive results, surgery or radiation therapy may be required. Operations are usually carried out without tall trepanation, a transnasal way. For radiation therapy, they are resorted in cases where the neoplasm has passed into a malignant form or if other forms of treatment do not bring positive results.

The consequences of elevated prolactin
Among the medications with a clearly pronounced effect in the treatment of hyperprolactinemia, it is worth identifying drug-based drugs (ergolin preparations), in particular - bromocriptine and Cabbergoline. The first one has some side properties, so many patients tend to receive Cabergolin. The course of treatment is usually long - it is about 1-3 years. In some cases, it may be necessary to receive drugs throughout life with low interruptions and minor dose adjustment. Also treatment is made by hormonal means.

There are folk methods for lowering the level of this hormone in the blood. However, it is necessary to understand that traditional medicine can be appropriate only if prolactin is slightly elevated, and the patient does not have prolactinoma. In any case, it is impossible to decide independently that you can drink with increased prolactin the funds of traditional medicine. You need to do this only after consulting with your doctor.

As a raw material for cooking eyelids and decoctions, helping to cope with hyperprolactinemia, seeds of Abraham Tree, herbal fees from hop, peony root, mother-in-law, adonis, mint, royalties, passiflores, laptops, ninewide. You can also take a Japanese laminarial powder, prepare infusions and decoctions of meadow striking, cuffs, Melissa, Valerians.

With increased prolactin, it is necessary to introduce products rich in folic acid into its diet

Elevated prolactin

Sleeping disorders, memory, attentiveness, increased fatigue, apathy, weakness are observed.

If prolactin is slightly elevated, and in drug therapy, there is no need yet, you can try to adjust the hormone level using a diet.

If hyperprolactinemia is caused by the pituitary adenomas, there is a chance of development and other consequences dangerous. Among them is to highlight hypocituitarism (Hipopituitarismus), paralysis of extracilla muscles, limiting field fields, reduction of visual acuity. Opinion expert

With elevated prolactin in the blood, it is possible (and necessary) to use products rich in folic acid. This substance contributes to the best degree of protein food, the overhaul of which is considered one of the reasons for the physiological increase in prolactin. Folic acid is contained in the liver, fatty varieties of fish, chicken eggs, low-fat meat, spinach, parsley, vegetables. Also it will be technly added to the diet of any nuts and seeds of flax.

It is recommended to reduce the number of consumed gluten-containing products, canned, smoked products.

Due to the possible change in food behavior and the tendency to overeating with elevated prolactin, you must carefully follow the daily caliper.

Reduced prolactin: How to increase folk remedies and herbs?

Not only the high content of the hormone in the blood can cause discomfort, its disadvantage is also able to cause a number of violations. In particular, the insufficient level of its development may indicate a shyhan syndrome or transferred pregnancy. Also, the reduced level of prolactin may be observed as a result of the reception of some medicines. It manifests itself in the form of lack of lactation after childbirth, amenorrhea, spontaneous interruptions of pregnancy, nervousness, swelling, etc.

  • There are folk methods to help increase the content of this hormone in the blood. However, you should understand that, like any alternative medicine, people's recipes must act as an additional, not fixed assets.
  • Before starting treatment, it is worth consulting a doctor.
  • What increases the level of prolactin, based on the experience of traditional medicine?
  • Raspberries. 4 tbsp. l. Washed colors and leaves of plants to fervent in the thermos, bay with two glasses of boiling water. Let it be broken within an hour, after which it is, regardless of meals.

Sage. 100 g of dry raw materials pour 2 liters of boiling water, let it stand and take three times a day in 100 ml.

Oregano To prepare a decoction to take 2 spoons of grass pour 300 ml. boiling water, let it be. Take small portions during the day, regardless of meals.

DONON. A decoction prepares from this plant. You need to take a spoonful of dry raw materials, pour boiling water with a glass and cook on a water bath for a quarter of an hour. Then give it to be broken and take 50 g three times a day.

Do not forget that plant fees, decoctions and infusions used by traditional medicine to normalize the level of prolactin in the blood can cause allergies. Therefore, if you have a tendency to atypical immune system reactions, it is necessary to conduct treatment with folk remedies very carefully.
  1. Evening primrose oil - an effective means for combating elevated prolactin
  2. Ginokomfort® offers a tool to help normalize the production of this hormone, normalize the menstrual cycle and avoid breast loading - evening primrose oil. This biologically active additive helps to rule the prolctine secretion rate, has a beneficial effect on the immune system, produces an antioxidant effect, struggling with inflammatory processes. The equipment includes natural ingredients, which are beneficial to women's well-being. This tool, like the whole line "Ginokomfort", has all the necessary quality certificates.
  3. Sources:
  4. Metabolic effects prolactin. Dzeranova L.K., Mokryshva N.G., Barmina I.I., Giniatullina E.N. // Bulletin reproductive health. - 2008, December. - P. 29-33.

  5. Reproduction and Energy Balance: The integrative role of prolactin. Romantic T.I. // Obesity and metabolism. - 2014. - №1. - P. 5-17.

  6. Modern approach to the treatment of women with pathological mactering. Gevorkyan MA Manukhin I.B. Fatalieva k.z. Manukhina E.I. // Medical advice. - 2010. - № 34. - P. 21-26.

  7. Metabolic effects prolactin. Dzeranova L.K., Mokryshva N.G., Barmina I.I. et al. // Bulletin reproductive health. - 2008 (4). - P. 29-32.
  8. Hyperprolactinemia in women and men. Melnichenko G.A., Marova E.I., Dzeranova L.K., Vaks V.V. // M. - 2007. - P. 45.
  9. The effect of hyperprolactinemia on the main indicators of fat metabolism. Kurlyandskaya R.M., Romanticova T.I. // Lege. doctor. - 2004. - 1. - P.73-75.
  10. https://www.medicalnewstoday.com/articles/322279.php.

https://www.pubfacts.com/detail/6301648/prolactin-enhanced-grooming-behavior-interaction-with-acth

https://www.uptodate.com/contents/high-prolactin-levels-and-prolactinomas-beyond-the-basics https://jci.org/articles/View/16530

Popular questions Prolactin - 25.12. What pills can be taken to reduce prolactin?

With increasing prolactin, revealed for the first time, it is necessary to carry out further. Repeated analysis on the level of prolactin and macroprolactin, the MGG of the pituitary gland to exclude or confirm prolactin. The results depends on the treatment tactics, therapy duration. At this stage, you can start the reception of ginokomfort the evening oil of the evening 2 capsules 2 times a day to 3 months, if the increase is physiological. Can hyperprolactinemia be the cause of the violation of the vaginal microflora and cause burning and itching outdoor genital organs? STIs - negative, thrush - no. In the smear - then high leukocytes and cocci, as I put the candles with lactobacteriums, then smear sticks and no leukocytes, but as soon as it passes a couple of weeks - everything is again. Itching and burning from the candles do not pass.

Hello! If with you have a disruption of the menstrual cycle, then this can lead to changes in the mucous sex tract. They become land, ranmine, lose elasticity. You need to adjust the hormonal background. In order to prevent inflammation, the use of gel ginokomfort with Malva extract is suitable, which will eliminate dryness and help restore the mucous membranes. Improved prolactin, 1612, handed over the 3rd day of the cycle. Please advise the medicine. The breast is swollen, the cycle is very swelling and there is an increase in body weight. It is necessary to determine macroprolactin, which will allow to understand what the increase in prolactin is associated with: with prolactine or symptomatic due to the reception of a number of drugs, emotional stress, manifestations of the endocrine disease, etc. Only the cause of the cause will help correctly assign the therapy.

Improved prolactin. I handed over the third day cycle-576. TSH, FSH, LH, estradiol - everything is normal. Other analyzes did not appoint the doctor. Ultrasound of a small pelvis normally, ultrasound

Milk glands is normal, but one breast is more sensitive. White selection chest, little. Monthly began to go very little. The doctor prescribed the cyclodinone first, then changed his mind and said three months to take Mastodinon. What to do, because no one called the reason for increasing prolactin. Hello! In your case, it is recommended to reconsider the analysis re-on prolactin and macroprolactin. You can define these hormones in any zen cycle. This will help in diagnostics: functional increase or should be excluded organic nature. The recommended drug stabilizes the functional disorders. It can be combined with an evening primrose oil, which is accepted by 2 capsules 2 times a day for 3 months.

For accurate diagnostics, contact a specialist

Galatherya is the release of milk or browse from the nipples in a woman, without a nursing baby with breasts. The cause of galactorei - hyperprolactinemia, at which the level of the prolactin hormone is elevated. Galactere can be in men, and in children.

Hormone prolactin

High prolactin is dangerous to health, like any other hormonal violation.

Reception of the endocrinologist, gynecologist - mammologist, oncologist - 1000 rubles. Consultation of the profile doctor according to the results of ultrasound, analyzes - 500 rubles. (optional).

Galactorian is not an independent disease, but a symptom of any disease associated with a hormonal imbalance. Therefore, by noting the selection from the chest or a child, it is necessary to immediately sign up to the oncologist. An experienced specialist accepts Diana in the clinic.

What is prolactin

Prolactin is a hormone that is distinguished from the front lobe of the pituitary gland. One of the main roles of prolactin is the secretion of milk in lactic glands in nursing mothers. It is also responsible for the correct functioning of the reproductive system. Hyperprolactinemia is an endocrine system disorder, in which the prolactin level is at a high level.

The prolctin secretion exhibits daily rhythm, that is, its concentration depends on the time of day. A higher hormone level is marked at night during sleep, during food, physical exertion or significant excitement.

The largest level of prolactin in the female body during pregnancy (hormone, produced in the pituitary gland, placenta, child pituitary gland). Then you can talk about natural hyperprolactineia, that is, excess prolactin. In all other cases, the increase in prolactin is a serious pathology.

Causes of hyperprolactiamia

  • Normally, healthy people have no fluids from the chest. In women, the discharge can be in pregnancy and, of course, during feeding, but after five months after the end of the lactation of separated from the chest should not be.
  • Most often, hyperprolactinemia causes hypofunction (decrease in activity) of the thyroid gland and adrenal cortex. The level of prolactin also increases the diseases of the chest, slimming, the adenoma of pituitary glands and other tumors, as well as cirrhosis of the liver, kidney tumors and bronchi.
  • The main causes of galactors are very unpleasant conditions:
  • small (2-3 cm) benign tumors in the field of pituitary
  • impairment of the thyroid gland and adrenal glands;

Ovarian diseases affecting their function (cysts, polycystic);

Reception of drugs changing hormonal background;

Renal and liver failure.

It is not relaxing for reasons, hyperprolactinemia also includes stress as mental and physical. It causes an increase in endorphins that increase the activity of the brain and the hypothalamus and, as a result, leads to an increase in the secretion of prolactin. The cause of the disease can be a long-term use of pharmacotherapy, such as, for example, neuroleptics.

These are not all reasons. Causes of lactogenic tinctures, for example, from Fennel, regular injury to the chest (rude sex, the use of sex toys - POMP, coarse linen, etc.), traumatization and disruption of nerve fibers in injuries and operations on the spinal cord etc. The spectrum of the cause is really wide and diverse, so only a good specialist will be able to identify the true problem.

It is not necessary to worry only in one case - if the Galactere has begun at a newborn baby. This condition is associated with the mother's hormonal balance during childbirth, so after a while everything will come to normal.

To identify the reasons for increasing prolactin, the doctor prescribes additional analyzes and research:

Symptoms of hyperprolactinemia in men, women, children As a rule, the disease is manifested by repeating headaches, depression, chest pain, obesity, skin problems and hypertrichosis. These symptoms are joined by the "tides" of heat and a decrease in sexual entry.

The patient is bothering constant selection from the chest: the liquid can be released dropwise, and maybe in large volumes. The women have a menstrual cycle, and sometimes menstruation completely stop, leading to infertility. With hyperprolactinemia, the skin is spoiled, fatty seborrhea and acne occurs, hair growth is observed on the face.

Clinical symptoms are also associated with diseases of the bone density (osteoporosis, osteopenia), a decrease in libido, a galattere, a violation of fertility (ability to conceive. Among the distinguishing symptoms associated with the disease - a decrease in visual acuity.

In the fight against elevated prolactin, women increase the secretion of men's hormones - androgen. Therefore, acne may appear on the face, and the hairs are growing in places typical of men - on face, abdomen, chest. In turn, the hair begins to fall out.

The hyperprolactinemia is diagnosed on the basis of the history of the disease, clinical examination and additional research. If the doctor suspects the pituitary tumor, an ophthalmological examination and brain studies are also necessary: ​​computed tomography and magnetic resonance tomography.

Hyperprolactinemium during pregnancy

If a woman takes drugs and pregnant, it is necessary to stop the treatment. Therefore, in addition to the level of prolactin, it is worth taking care of the future child. If the hormone level is stable, and the future mother is under the supervision of a doctor, pregnancy must pass without any problems.

The identification of hyperprolactinemia does not exclude the occurrence of pregnancy. This disease may make it difficult to or delay it, but the diagnosis of illness and its treatment - gives a chance to motherhood.

  • How to check the level of prolactin: Prolactin tests
  • To find out the level of this substance, you need to pass the blood test to hormones. Before studying the level of prolactin in the blood, it is necessary to refrain from eating and drinking. It is best to pass tests after awakening, between 8 and 10 in the morning. On the day before the examination should not be overworked and undergoing stress:

The correct concentration of prolactin in the blood:

  • 4.5-33 ng / ml norm in the follicular phase;
  • 4.9-40 ng / ml Norm in lutein phase
  • The results obtained can be interpreted according to the scheme:
  • 5-25 ng / ml - normally;

Above 25 ng / ml - disruption of the menstrual cycle and anoint cycles;

Above 50 ng / ml - the latency of the menstrual cycle;

Above 100 ng / ml - the risk of a pituitary tumor.

The above rules of prolactin are used in deciphering analyzes for hormones with a gynecologist or an endocrinologist. Specialists, analyzing data, take into account many factors that can affect the results. For example, when assessing hormonal factors, age is important, the presence of concomitant pathologies and hormone therapy, etc.

It is also important to understand that another hormone is responsible for the corresponding level of prolactin - dopamine. It slows down prolactin production (the greater the level of dopamine - the less prolactin is allocated). Another regulator of the prolactin secretion is estrogens that increase its production and secretion. Therefore, the doctor appoints additional analyzes for hormones, it helps to identify the true causes of pathology and appoint proper treatment. How to treat hyperprolaktemia

  • To cure a galactore, you need to find out the causes of hyperprolactinemia. Since the increased selection of prolactin occurs in many states, it is important to carry out the correct diagnosis.
  • First, prescribe blood tests (clinical, biochemistry and hormones). The survey identifies hormonal failures and malfunctions in the work of the internal organs (liver, kidneys).
  • Then, depending on the results, carry out:
  • ultrasound examination of internal genital organs to detect cyst;

Ultrasound of the thyroid gland to eliminate the nodes in its tissues affecting the hormonal background;

Rengenography of the Turkish saddle - the skull area in which the pituitary is located to eliminate the tumor;

  • MRI and CT head. According to the results of the surveys, they find out whether there are neoplasms in other brain departments;
  • Depending on the cause of the disease, two types of treatment can be used - drug or surgical (tumors leading to hyperprolactinemia, which do not exceed 1 centimeter can be treated pharmacologically).
  • Treatment depends on what cause caused hyperprolactinemia:
  • With hormonal imbalance and polycystic ovaries, drugs normalizing hormonal background are prescribed. Helps the reception of contraceptive pills and means containing estrogens. Medicines are selected by the doctor individually according to the results of the tests;
  • If problems are detected with thyroid gland, iodine preparations are prescribed;

To suppress milk generation, drugs are shown that overwhelm prolctine secretion;

  • Small tumors in the pituitary gland are treated with the appointment of chemotherapy, and large neoplasms are removed.
  • Good results give the use of basic drug therapy in combination with the purpose of the dietary supplements and drugs from plant components.
  • The following drugs are often used:

Bromocriptine (Bromergon, Ergolaktyna, Bromocriptine) is an effective preparation, but can cause side effects such as nausea and dizziness.

Norprolac is an effective, pretty expensive drug.

The achievement is an inexpensive drug (prescribed with caution, as it has contraindications.

Naturally, drugs select exclusively an endocrinologist and only after receiving all the results of the tests. Incorrect hormone therapy will lead to an even greater hormonal failure, which will turn into obesity, diabetes, renal and hepatic failure and other complications.

Neurosurgical treatment is recommended if the drugs do not sufficiently reduce the level of prolactin or intolerance (drug resistance) or the doctor detected a tumor. Where they treat hyperprolaktemia in St. Petersburg, prices

In the clinic of Diana in St. Petersburg accepts an experienced endocrinologist - a doctor with the highest qualifying category. Here you can pass all the tests and go through the ultrasound on the newest device of the expert class. The cost of receiving an endocrinologist is only 1000 rubles. Reception according to the results of diagnostics - 500 rubles. Price ultrasound of the mammary glands - 1000 rubles.

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Prolactin

(Lutheotropin, Mammotropin) - a pituitary hormone, which is responsible for the growth of the mammary glands and ensures the production of breast milk in women. In small quantities is contained in the body of men.

A distinctive feature of prolactin are sharp fluctuations

which may be associated with sleep, medication, active sexual stimulation, chest injury. In healthy people, the hormone level is normalized within a few hours. Long-term increases in blood prolactin requires adjustment, as they can cause health disorders.

Hyperprolactinemia

- The high content of prolactin in the blood is found in 1% of women. Increased hormone production

Pregnancy

and the lactation period may have serious consequences, up to termination of menstruation and

infertility

If you have found a mistake, please select the text fragment and click

. The increase in prolactin in men is extremely rare.

To determine the level of prolactin, it is required to pass blood from the vein.

The role of prolactin in the body

It is produced by the front fraction of the pituitary. His synthesis regulates another hormone -

Dopamine

which is secreted by the hypothalamus kernels. Finding on the bloodstream in the pituitary gland, it blocks the selection of prolactin.

Progesterone

generated by the yellow bodies of the ovaries in the second half

menstrual cycle

Also reduces the secretion of prolactin.

Daily rhythm secretion

The highest level of hormone is celebrated in the phase of deep sleep and immediately after the rise, then its concentration falls. In this regard, it is recommended to take the analysis about 3 hours after awakening.

How prolactin acts

Milk glands cells have receptors that bind to prolactin molecules. The result of this interaction becomes the active division of cells, due to which the robs and ducts of the mammary glands occur, as well as the production of milk. The same receptors are found in the cells of other organs, but the effect of prolactin on them is not fully established.

Forms prolactin

In the human body there are several forms of prolactin.

Monomeric

- The most active, it causes appropriate changes in the body.

Dimeric

The form of prolactin is not associated with cell receptors.
Polymer The form does not pass through the wall of the capillaries due to the large size of the molecule and does not affect the body. In the presence of a polymer and dimeric form, the prolactin analysis shows exceeding the norm, but at the same time the symptoms of hyperprolactinemia does not occur, and treatment is not required.
Functions prolactin in the body Women

Men

Development of mammary glands during puberty. Rights of the mammary glands due to an increase in poles and ducts. Development of colostrum and milk Regulation of the production of estrogen. Regulation of the phase of the yellow body and the menstrual cycle. Prevent pregnancy during lactation. Formation of attachment to the child. Regulation of the water-salt balance. Normalization of metabolism. Strengthening bone tissue, enriching it by calcium.

Regulation of the water-salt balance. Normalization of metabolism. Maintain a normal level of testosterone. Normal maturation of spermatozoa, an increase in their mobility. Growth of seed bubbles and prostate. Height of muscle mass. Bone strengthening, improving calcium suction.

и

Selection of prolactin during pregnancy and after delivery

During pregnancy, the level of prolactin rises 20 times, which is caused by high levels

estrogen

progesterone

. High doses of prolactin provoke an increase in breasts and darkening of near-block circles in pregnant women. In this case, estrogen and progesterone block the production of breast milk, despite the high levels of progesterone. Immediately after the birth, the concentration of estrogen and progesterone falls and the colostrum begins to stand out, and then milk.

Prolactin stabilizes 4-6 weeks after the child's birth. But its level remains steadily high for several more months due to the stimulation of nipples during feeding, which allows you to maintain lactation. This mechanism explains the fact that frequent applying to the breast increases the amount of milk.
Polymer The form does not pass through the wall of the capillaries due to the large size of the molecule and does not affect the body. In the presence of a polymer and dimeric form, the prolactin analysis shows exceeding the norm, but at the same time the symptoms of hyperprolactinemia does not occur, and treatment is not required.
The high level of prolactin in the nursing mother protects it from re-pregnancy. It suppresses the formation of gonadotropic pituitary hormones and warns ovulation and the development of a yellow body, which is manifested by the lack of menstrual in the first months of breastfeeding. Occasionally, pregnancy in such conditions may still come. Why do prolactin test assign? (Main readings for this analysis)

Indications for Prolactin Analysis

Menstrual disorders. Breast pathology. Galactere - the release of milk is not influential with breastfeeding. Amenorrhea - no menstruation. Symptoms of hyperandrode (excess of male sex hormones) - angry rash, excess extension on the body. Infertility. Unbearable pregnancy - miscarriage, premature birth. Hypothyroidism is a disease associated with a low level of thyroid hormones. Suspicion of the pituitary tumor of the neoplasm in the ovaries - cysts, tumors.

Gynecomastia is an increase in the mammary glands. Infertility. Lack of spermatozoa in ejaculate. Erectile dysfunction - impotence. Suspicion of the pituitary tumor.

Signs of increased level of prolactin at different ages
The main signs of increasing prolactin in women - It is the release of nipples and delay of menstruation. The symptoms of increased prolactin are closely related to its ability to block the effect of female sex hormones - estrogen and progesterone. In men, on the contrary, prolactin enhances the action of estrogen, but blocks testosterone.
Signs of raising prolactin Girls

Boys

Signs of increased level of prolactin at different ages
Polymer The form does not pass through the wall of the capillaries due to the large size of the molecule and does not affect the body. In the presence of a polymer and dimeric form, the prolactin analysis shows exceeding the norm, but at the same time the symptoms of hyperprolactinemia does not occur, and treatment is not required.
Delay of puberty. Late periods or their absence - primary amenorrhea. Menstrual disorders. Underdevelopment of external genital organs and mammary glands. Selection of liquid from nipples. Delay of puberty. Increase the chest glands. Characteristic body proportions: long arms and legs, highly located waist, hips wider shoulders, deposition of fat in the area of ​​nipples, the bottom of the belly and the lower back. Weak muscles. High voice. Tests (testicles) are reduced. There is no sexual attraction and interest in sex.

Prolonged exposure to high doses of prolactin in adults causes violations in the work of various organs and systems.

Discharge from the mammary glands. The released fluid can be transparent or resemble breast milk. The amount varies from several drops when pressing up to several milliliters and unauthorized expiration. An increase in the mammary glands due to the growth of the epithelium of poles and ducts. Mastopathy - seals in lactic glands, formation of cyst and aden. Violation of menstrual function: irregular menstruation, abundant and painful bleeding. Amenorrhea - termination of menstruation for 6 or more months. Infertility. The high level of prolactin blocks the ovarian hormones, disrupting the ripening of the egg and ovulation. This makes the impossibility of pregnancy. Unbearable pregnancy. Frigidity is the lack of desire to have sex. Polycystic ovarian syndrome. High prolactin violates ovulation processes, as a result, numerous cysts are formed on the site of ripened follicles. Improving body weight associated with water delay and increased fatty deposits. Angry rash on the face and upper half of the body. Frequent bone fractures and multiple caries due to the flushing of calcium salts. Disturbance of peripheral vision, bias in the eyes when squeezing the eye nerves by the adenoma pituitary. Disorders of emotional stability and sleep.

Reducing sexual entry and impairment of potency, which is caused by a decrease in testosterone. Gynecomastia - the growth of the chest glands. Obesity. Frequent fractures and multiple caries. Violation of vision in large pituitary adenoma, squeezing eye nerves. Reduced vital tone, chronic fatigue.
Polymer The form does not pass through the wall of the capillaries due to the large size of the molecule and does not affect the body. In the presence of a polymer and dimeric form, the prolactin analysis shows exceeding the norm, but at the same time the symptoms of hyperprolactinemia does not occur, and treatment is not required.
Signs of reduced level prolactin The reduction of prolactin phenomenon is quite rare. It may be due to the damage to the front proportion of the pituitary gland of various nature or with the increased sensitivity of the body to the dopamine that prevents the production of prolactin.

Symptoms of reduced level prolactin

Infertility. Menstrual disorders. Miscarriages in the early periods of pregnancy. Lack of milk in the lactation period. Migraine attacks. The oppressed state of obsessive fears. Hypertensive crises. Stressed hair growth on face and back.

The deterioration of sperm quality, reduced sperm mobility. Reduced potency. Prostatitis. Emotional instability, anxiety.
  • How to prepare for test for prolactin
  • To obtain the most accurate results of the analysis of the minimum for 3 days, it is necessary to cancel the reception of drugs affecting the synthesis of prolactin. Their list is presented in the following sections of the article. If there is no ability to cancel drugs, then you must inform the laboratory staff about the preparations taken and their dosage.
  • During the day before the study, if possible, refrain from:
  • stress;
  • injuries;
  • smoking;
  • alcohol;
  • psychotropic substances;
  • abundance of protein and carbohydrate food;
  • interchange;
  • Irritation of Nipples and Area - Sexual Stimulation, Close Lingerie;

thermal procedures - baths, hot bath;

lack of sleep;

physical exertion.

If it was not possible to avoid these factors, it was recommended to postpone the surrender of the analysis for 3 days.

In the morning, the day of the tests you need to abandon food, tea and coffee.

Blood on prolactin is required to pass in the morning hours: from 9 to 11.

What day of the menstrual cycle take blood for analysis?

The level of prolactin in the blood does not depend on the day of the menstrual cycle. Therefore, we can pass the analysis to prolactin on any day. However, some endocrinets indicate that the best period for passing the analysis to prolactin is 5-8 days of the menstrual cycle.
Polymer
Normal values ​​prolactin Categories
Normal NG / ml Over 17 years old
4,79-23.3 Pregnancy I Trimester
23.5-94.0 Pregnancy II Trimester
The form does not pass through the wall of the capillaries due to the large size of the molecule and does not affect the body. In the presence of a polymer and dimeric form, the prolactin analysis shows exceeding the norm, but at the same time the symptoms of hyperprolactinemia does not occur, and treatment is not required.
94.0-282.0 Pregnancy III Trimester
 
188.0-470.0.
Over 17 years old 4,04-15,2
Children up to 16 years old Girls ng / ml Children up to 16 years old Boys ng / ml
1-5 years old 2.7-19.5 1-5 years old 3.9-20.1
6-10 years old 2.7-22.3 6-10 years old 2.6-16,1
11-13 years old 2,0-31,6 11-13 years old 2.3-22.3

14-17 years old

3.7-23.3

  • 4.7-16.7 It should be borne in mind that the level of prolactin is not stable and a healthy person is possible significant physiological jumps. If the norm of prolactin is elevated 1.5-2 times, but there are no symptoms, it is recommended to re-pass the analysis after 10-14 days.
  • Under which pathologies are prolactin rates? Prolactinoma
  • (Microenoma to 1 cm, macroenoma over 1 cm) is a benign tumor of the front part of the pituitary gland from iron tissue producing prolactin. The pathology indicates the level of prolactin in the blood of more than 250 ng / l. Tumors of the hypothalamus,
  • Violating the production of dopamine, opposing prolactin. Tumors of ovarian or adrenal glands,
  • Drawing estrogens. Diseases of the bronchopulmonary system
  • (Bronchitis, tracheit, pneumonia) Autoimmune diseases
  • (arthritis, systemic red lupus). An antibody attack on the pituitary gland leads to enhanced prolactin production. Hormonal disorders after abortion
  • accompanied by sharp jumps of genital hormones and prolactin. Diseases of the endocrine system
  • (acromegaly, hypothyroidism). In response to a decrease in the concentration of thyroid hormones, the hypothalamus increases the secretion of thyrotropin-rilizing hormone, which is designed to activate the work of the thyroid gland. At the same time, it stimulates and produce prolactin. Renal failure
. The violation of the excretory function of the kidneys contributes to the accumulation of prolactin in the body.
  • Liver damage
  • (hepatitis, hepatosis, cirrhosis) is likely to violate the robot pituitary.
  • Situations in which prolactin can increase in healthy people (physiological hyperprolactinemia):
  • pregnancy;
  • breastfeeding period;
  • Babies in the period from birth to 3 months;
  • breast injury;
  • abortion;
  • Endometrial scraping;
  • transferred surgical operations on the chest;
  • Sexual contact, intensive stimulation of nipples;
  • stress;
  • Hypoglycemia - low blood sugar;
  • high protein diet;
  • overheating, visiting the sauna, bath;
  • severe physical training;
  • injuries;
  • pain;
  • hypovitaminosis vitamin B6 (pyridoxine);
  • Reception of medicines:
  • Hormonal preparations containing estrogen and contraceptives;
  • Dopamine blockers - Sulpirid, Domperidon;
  • neuroleptics - haloperidol, sulpirid, perfenazine;
  • Antiwheat - Cerukal, Chlorpromazine, Aeron;

Tricyclic antidepressants - hanoperidol, imipramine, amitriptyline;

  • hypotensive drugs - reserpine, verapamil; Cocaine, Opiato, Promedol.
  • What pathologies are prolactin indicators reduced? Apoplexing pituitary glands
  • (Shihan's syndrome) is an acute circulatory disorder leading to necrosis in the pituitary adenome. Massive blood loss
  • Over 500 ml, for example, bleeding after delivery. Brain tumors
  • leading to squeezing pituitary. Tuberculosis pituitary gland
  • - Rare shape of tuberculosis. Radiation therapy
, caused the destruction of pituitary cells;
  • Brain-brain injuries
  • accompanied by edema or pituitary damage.
  • Situations in which prolactin is reduced in healthy people:
  • Menage of pregnancy Over 41 weeks;
  • smoking and alcoholism;
  • dehydration;
  • starvation;
  • age older than 50 years;
  • Durable medicines:
  • anti-epileptic - valproic acid, phenytoin, carbamazepine;
  • dopaminergic means - levodopa, bromocriptine, dopamine;
  • hormonal drugs - terguurd, dexamethasone, naparelin, danazole, ciproterone, epostan, calcitonin, tamoxifen, mifepristone;

anti-tuberculosis - rifampicin;

hypotensive - nifedipine;

Wriodes - Morphine.

How do you reduce the level of prolactin in a woman?

  1. Before proceeding with the treatment of increased prolactin, it is necessary to establish the cause of hyperprolactinemia.
  2. Medical examination
  3. Consists of several stages.
  4. Computed tomography KT, magnetic resonance tomography MRI or X-ray skull in 2 projections to eliminate the pituitary tumor.
  5. Study of the function of the thyroid gland to exclude hypothyroidism - ultrasound.
  • Pregnancy test for female reproductive age. If there is a chance that the woman does not know about the occurrence of pregnancy.
  • Biochemical blood test for determining the condition of the liver and kidneys.
  • Hormone tests for eliminating diseases of the endocrine system, accompanied by raising prolactin:
  • TG - thyroid hormone thyroid gland.
  • IFR-1 - Insulin-like growth factor 1, which regulates the secretion of somatotropin.
LG - luteinizing hormone of the front lobe of the pituitary gland.
  1. FSH is a follicle-stimulating hormone of the front lobe of the pituitary gland. Determining the level of macroprolactin (inactive forms) by polyethylene glycol-precipitation method.
  • Treatment of hyperprolactinemia depends on the reasons that caused the increase in prolactin
  • Redean hormonal therapy.
  • Treatment of diseases of the endocrine system leads to normalization of hormonal status and reduced prolactin. Sometimes drugs have to take life. Depending on the pathology detected, assign:
analogs of thyroxine thyroid hormone (euticox, l-thyroxine);

:

adrenal hormones (hydrocortisone, prednisone, flooding);

,

Estrogen antagonists (tamoxifen) increase the sensitivity of receptors to estrogen.

и

Indications

.

Hypothyroidism

Polycystic ovarian

Insufficiency of adrenal glands

,

Contraindications

.

: Individual intolerance to the components of the drug,

Myocardial infarction

  1. myocarditis Efficiency 2. With properly selected hormone therapy, the effectiveness of treatment is high.
analogs of thyroxine thyroid hormone (euticox, l-thyroxine);

Suppression of prolactin synthesis.

Hypothyroidism

Apply dirtamic agonists d

-receptors. Parlodel at 2.5-3.5 mg per day, lizuride of 0.05-0.075 mg, reaches 0.5 mg 1 time per week. These drugs are associated with dopamine receptors in the brain, due to which the pituitary glands allocates less prolactin molecules. The hormonal activity of the tumor and its size decreases, lactation is suppressed and the menstrual cycle is normalized. The dosage and duration of the reception is determined individually, based on the results of the tests.

: prolactinoma, micro and macroenomes pituitary.

: Hypersensitivity to the components of the drug,

hypertonic disease

  1. leading to squeezing pituitary. , Myocardial infarction, myocarditis, benign tumors of the mammary glands.
analogs of thyroxine thyroid hormone (euticox, l-thyroxine);

Efficiency

High. Most patients avoid the operation to remove the pituitary tumor.

. The destruction of the pituitary tumor ionizing radiation. It is combined with medicinal therapy or is carried out after surgical treatment.

: Hypersensitivity to the components of the drug,

: Large pituitary tumors, non-drug therapy.

  1. Contraindications Limphopal, leukopenia, thrombocytopenia, anemia, diseases of the nervous system, diseases, accompanied by increasing temperature, purulent or inflammatory processes in the field of irradiation, diseases of the cardiovascular and respiratory system, renal failure.
analogs of thyroxine thyroid hormone (euticox, l-thyroxine);

High, combined with other methods of treatment.

Surgery

. The removal of the pituitary tumor is carried out through the nasal sinuses.

: Violations of vision, the ineffectiveness of drug treatment.

,

Contraindications.

,

Pregnancy, children and senile age, inflammatory diseases (

hymorit

: Hypersensitivity to the components of the drug,

sinusitis

tonsillitis

), acute diseases and aggravation of chronic diseases.

High in microenome, tumors are less than 10 mm. With large adenomas, the probability of re-appearance of a tumor is 20-40%.

  1. Asymptomatic macroprolactinemia in women does not require specific treatment. If the amount of inactive forms of prolactin increased in the blood, which are not associated with cell receptors, then there are no symptoms - regular menstrual cycle, there are no highlights from nipples. At the same time, the analysis shows exceeding the norm of prolactin. In Macroprolactiamia, there is no need to reduce the level of prolactin.
  2. How to reduce the level of prolactin in a man?
  3. The survey algorithm to establish the cause of increasing prolactin in men.
  4. X-ray skulls in 2 projections, CT or MRI to detect the neoplasm in the pituitary gland.
  • Ultrasound of the thyroid gland for the diagnosis of hypothyroidism.
  • Biochemical blood test for detecting signs of liver and kidney disease.
  • Hormone tests for eliminating diseases of the endocrine system, accompanied by raising prolactin:
  • Hormone tests for identifying diseases of the endocrine system:
TTG - thyroid hormone thyroid gland
  1. IFR-1 - Insulin-like growth factor 1 which regulates the secretion of somatotropin. FSH - follicularity
analogs of thyroxine thyroid hormone (euticox, l-thyroxine);

Treatment is appointed based on the results of the patient's survey.

Hypothyroidism

Suppression of prolactin synthesis.

: Hypersensitivity to the components of the drug,

Reception of drugs to reduce the secretion of prolactin. They contribute to a decrease in the tumor and eliminate the symptoms of the disease. Parlodel at 0.6-7.5 mg per day, lizuride at 0.05-0.075 mg per day, and their analogs - pergolid and canbergoline. Preparations are prescribed from minimal doses, gradually increasing the reception of the drug in accordance with the recommendations of the doctor.

  1. FSH is a follicle-stimulating hormone of the front lobe of the pituitary gland. : Prolactinoma, pituitary adenoma, brain injury and other pathologies provoking prolactin increase.
analogs of thyroxine thyroid hormone (euticox, l-thyroxine);

: Individual intolerance to preparations, hypertension, myocardial infarction, myocarditis, benign tumors of the mammary glands.

Hypothyroidism

High. Most patients have taps to avoid operation.

: Individual intolerance to the components of the drug,

With hypothyroidism, a synthetic hormone of the thyroid gland is prescribed (euticox, l-thyroxine). If the adrenal function is violated, the analogues of their hormones are taken (hydrocortisone, prednisone, flooding). The reduction of the hormonal balance leads to normalization of prolactin.

  1. leading to squeezing pituitary. : Hypothyroidism, states after operations on the thyroid gland and insufficiency of adrenal glands.
analogs of thyroxine thyroid hormone (euticox, l-thyroxine);

: Individual intolerance to the components of the drug, myocardial infarction, myocarditis.

High. Most patients avoid the operation to remove the pituitary tumor.

High with proper selection of dose of the drug. Perhaps it will be necessary for lifetime taking drugs.

: Hypersensitivity to the components of the drug,

: Large pituitary tumors, non-drug therapy.

  1. Contraindications . Impact on the pituitary tumor ionizing radiation. Fits with medicinal therapy or after surgical removal of the tumor. Perhaps remote irradiation or administration of isotopes in tumor tissue.
analogs of thyroxine thyroid hormone (euticox, l-thyroxine);

: Whole pituitary tumors 1-3 cm, non-drug therapy.

Surgery

The distance to the optic nerves is less than 5 mm, an increase in the level of lymphocytes, leukocytes, platelets, diseases of the nervous system, an increase in temperature, purulent or inflammatory foci in the area of ​​irradiation, diseases of the respiratory system, renal and heart failure.

: Violations of vision, the ineffectiveness of drug treatment.

. Removal of the pituitary tumor through the nasal sinuses using an endoscopic surgical instrument. Macroenomes, the size of more than 2 cm, are removed by trepanication of the skull.

: Hypersensitivity to the components of the drug,

: Violations of vision, the ineffectiveness of drug treatment, hemorrhage into the tumor.

Senile age, foci of inflammation in the head area (

, sinusitis, tonsillitis), acute diseases and aggravation of chronic diseases, noncompensated heart defects and renal failure.

Why the prolactin is raised in women

High in microenome, tumors are less than 10 mm. With large adenoma over 2 cm, the probability of re-appearance of the tumor is 15%.

The human body, and especially the body of the woman, is under thorough control of various hormones, which, interacting with each other, with organs and tissues, control not only a variety of exchange processes, but also responsible for behavior. Most hormones are synthesized by the organism in small quantities, as these substances are very active.

Prolactin is one of the hormones, without which it is impossible to imagine a working female organism. This biologically active substance is produced in a hypophysies in very small quantities.

  • Why need prolactin
  • The study of the features and functions of prolactin is still conducted by scientists from various countries. To date, it is reliably known that this hormone provides a woman's normal operation of a childbearing function, with its absence or excess it is impossible to carry and the birth of offspring.
  • Prolactin attribute the following functions:
  • Prolactin activates the processes of the growth of the mammary glands as soon as the representative of the beautiful floor is included in the degenerate age;
  • Thanks to this hormone, milk is produced during the feeding of a newborn baby chest;
  • Thanks to the prolactin, it is possible to maintain a yellow body, which matures in female ovaries and is then released so that it is possible to conceive a child;

Prolactin retains the level of progesterone at a stable mark, without which the pregnancy is impossible;

  • The biologically active substance contributes to the formation and consolidation of maternal instinct after the child appeared on the light;
  • With the help of prolactin, the production of androgens adrenal glands is regulated.
  • It is mistaken to believe that prolactin is a purely female hormone. Although in smaller quantities, but in the men's body it is also present and performs the following functions there:

provides normal spermatogenesis processes;

controls the amount of the secret generated by the prostate;

Controls the synthesis processes in the testosterone organism.

Although prolactin in the body and is produced in very small quantities, it provides normal functioning in many aspects, and any deviations from the norm affect the health of the patient.

  • Signs of deviations from the norm
  • Prolactin is a hormone that is not studied during standard analyzes. To obtain numbers showing the level of this biologically active substance in the blood, it is necessary to refer to the doctor who will give a referral to a special analysis.
  • The reasons for passing the analysis to the level of prolactin can be the following symptoms that are concerned with a woman:
  • any disorders from the menstruation cycle (too abundant or scanty, rare discharge, etc.);
  • long and unsuccessful attempts to conceive and endure a child;
  • Galactorian outside the period of natural postpartum lactation (the release of milk from the chest is a symptom of excess prolactin in 70; women);
  • pronounced headaches or gradual loss of vision (mainly the pituitary tumor is diagnosed with such complaints);
  • active growth of hair cover on the face (found quite rare, no more than 20% of women);
  • Problems with skin (acne, dermatitis, acne, etc.);
  • Reducing libido;

depressive states and insomnia;

Osteoporotic damage to bone tissue;

Gradually progressive reduction in memory.

The prolactin level cannot increase or decrease without objective reasons, and that is why it is important to understand when diagnosis is necessary.

  • What is the norm of prolactin in women?
  • Many doctors sharpen the attention of the patients on the fact that the high level of prolactin in the blood does not always lead to the development of any negative symptoms. Cases are often recorded when a woman has a high level of prolactin, but there are no symptoms of pathologies (regular and standard menstrual cycle, light conception and childbirth) and, on the contrary, a woman can have a very slight jump of the indicator, and the symptoms are obvious.
  • This is explained very simple. In the blood, prolactin may be simultaneously in four different states:
  • small;

large;

macro;

Glycosylated.

Each of these forms of hormones has its impact on the female organism. The most active is the microprolactin, which circulates in the blood in a free state. The main varieties of the hormone are referred to as related, and therefore there are no such expressed effects as microprolakin.

For a woman, the norm will be considered the indicator from 600 μED / ml. If an increase of up to 1000 μED / ml is noted, then they say the "soft" jump of an indicator, which is not regarded by doctors, as very dangerous. If analyzes show a higher level of prolactin, then the diagnostic search begins, which should reveal the cause of deviations.

For more information about the norms of prolactin in women, see the table.

For more information about the norms of prolactin in women, see the table.

Table: Norm prolactin in women by age

Age

Measurement unit MME / ml

Up to 12 months

42 - 6339 MME / ml

0.88 - 133.12 ng / ml

1-4 years

212 - 3625 MME / ml

4,45 - 76.13 ng / ml

4-7 years old

339 - 2777 MME / ml

7.12 - 58.32 ng / ml

7-10 years old

64 - 2735 MME / ml

1.34 - 57.44 ng / ml

10-13 years old

191 - 2735 MME / ml

4.01 - 57.44 ng / ml

13-16 years old

339 - 3519 MME / ml

7.12 - 73.9 ng / ml

16-18 years old

445 - 3901 MME / ml

9.35 - 81.92 ng / ml

18-20 years old

860 - 4960 MME / ml

18.06 - 104.16 ng / ml

20-45 years old

252 - 504 MME / l

4.5 - 23 ng / ml

Menopause

170 - 330 MME / l

3 -15 ng / ml

Immediately before the start of the diagnostic search also estimates the percentage of microprolactin with its other forms. If microprolactin is a lot (more than 60%), then pathology is dangerous. If the microprolakintin is small (less than 40%), it means that the bound and inactive hormone is mainly entered into the blood, which is not so dangerous.

Why is prolactin rises?

Hyperprolactinemia can occur with different diseases as an additional symptom of pathology. Before the start of a more detailed diagnosis, the doctor turns out whether there was no physiological reasons that could increase the figure. Physiological reasons include recent sexual intercourse, active physical exertion.

If it's not in physiological reasons, they must be established during the survey.

1. Diverse pathology pituitary

The most often diagnosed with such a disease as the pituitary prolactin (hormonally active tumor). Such neoplasms can be identified with a detailed examination from a quarter of the world's population, but they do not allow themselves to know any pronounced symptoms.

For women, it is characterized by a benign development of prolactinoma (the tumor is small and grows slowly). At the same time, the discovery is often completely random if the woman appeals to the doctor about another disease.

Also, the increase in the level of prolactin may be observed if any malignant tumor interrupts the normal message between the pituitary gland and the hypothalamus.

2. Primary type hypothyroidism

Recent observations have shown that many women suffering from hypothyroidism increases the level of prolactin in the blood. Why reducing the level of thyroid hormones is so expressed effect on the level of prolactin, has not yet been established. Many scientists suggest that this is due to the participation of the structure of the brain in regulating the allocation of thyroid hormones.

3. Syndrome of ovarian polycystosis (SPE)

Spades - Another often reason for increasing the level of prolactin. Why, when a multiple cyst is found in the ovaries, prolactin production processes have not yet been established.

4. Manipulation on the chest or damage

Improving the level of prolactin is observed in women who have undergone an operation on the chest or suffering from the virus of a shearing depriving in the same region. In this case, the recording level jump is associated with the fact that the receptors of the chest glands are irritated.

5. idiopathic increase in hormone levels

Many people have prolactinemia wearing idiopathic character (there are no objective reasons so that the hormone levels have increased). In this case, the blood varieties of prolactin circulate in the blood, and treatment is not required.

6. Various tumors

Often, hypothalamus tumors or neoplasms that are capable of producing estrogens lead to an increase in the level of prolactin.

It is important to remember that some drugs are able to provoke the increase in the level of prolactin. If a woman systematically applies any medical drugs, it must necessarily inform his doctor about it.

Why is prolactin decrease?

Reducing the level of prolactin or hypopronology is a deviation found in clinical practice much less often than hyperprolactinemia. The reasons for its development are less.

1. Shahan Syndrome (pituitary infarction)

Shahan syndrome is found in women only after childbirth. It is characterized by the infarction of pituitary tissues due to the big blood loss during the generic process. A woman who survived Shahan Syndrome cannot feed the child with breast milk. If the hypophized tissue ischemia was very significant, special replacement therapy is assigned.

2. Receive some medicines

Various diuretics, pyridoxine and dopamine are able to reduce the level of prolactin in the blood. Also, the indicator of this hormone becomes less if the woman is an active smoker.

  • Prolactin can also be reduced after sleep, since at this time it is produced by a hypophysia less active.
  • Research to clarify the diagnosis
  • Conclusions about the state of health of women are not made according to the results of one analysis for prolactin. The analysis repeat the minimum three times, and if deviations are observed in all three cases, the representative of the excellent gender is assigned the following additional diagnostic measures:
  • control of the level of hormone thyroid systems;

study with the help of MRI and CT the pituitary zone and hypothalamus;

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